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Synthesis of functionalized Pyridines and Quinolines by Palladium-Catalyzed Cross-Coupling Reactions
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2018 |
| Abstract | This thesis deals with the functionalization of pentahalogenated pyridines and dihalogenated quinolines through palladium catalyzed cross coupling reactions. This includes the synthesis, chemo-selective arylation and alkynylation of 4-bromo-2,3,5trichloro-6-iodopyridine using Suzuki-Miyaura and Sonogashira reactions. Synthesized pentaalkynylated pyridines show strong fluorescence and were consequently analysed by UVNisand fluorescence spectroscopy. The chemo-selective arylation of 4,6dihalogenated-2-(trifluoromethyl) quinoline by Suzuki-Miyaura reaction was studied. Obtained derivatives were evaluated for their potential to inhibit ecto-5'-nucleotidase for both human and rat. Besides, the synthesis of indolo [2,3-c] quinolines was studied by sequential chemo-selective Suzuki-Miyaura reaction followed by double C-N coupling starting from 3-bromo-4-iodoquinoline. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.mathnat.uni-rostock.de/fileadmin/uni-rostock/Alle_MNF/MNF/Studium_Promotion/Zusammenfassung_Dissertation/2018/Rodisnel_Perdomo_Rivera.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |