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Palladium-catalyzed coupling reactions on functionalized 2-trifluoromethyl-4-chromenone scaffolds. Synthesis of highly functionalized trifluoromethyl-heterocycles.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Izquierdo, Javier Jain, Atul D. Abdulkadir, Sarki A. Schiltz, Gary E. |
| Copyright Year | 2019 |
| Abstract | The chromenone core is a ubiquitous group in biologically-active natural products and has been extensively used in organic synthesis. Fluorine derived compounds, including those with a trifluoromethyl group (-CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogs. We have found that 2-trifluoromethyl chromenones can be readily functionalized in the 8- and 7-positions, providing chromenones cores of high structural complexity which are excellent precursors for numerous trifluoromethyl-heterocycles. |
| Starting Page | 1342 |
| Ending Page | 1352 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1055/s-0037-1610669 |
| Alternate Webpage(s) | https://www.thieme-connect.com/media/synthesis/EFirst/supmat/sup_ss-2018-m0626-op_10-1055_s-0037-1610669.pdf |
| PubMed reference number | 31274934 |
| Alternate Webpage(s) | https://doi.org/10.1055/s-0037-1610669 |
| Volume Number | 51 |
| Issue Number | 6 |
| Journal | Synthesis |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |