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Correlates of osteoporosis in chronic obstructive pulmonary disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Incalzi, Raffaele Antonelli Caradonna, Paolo Ranieri, Prudenza Basso, Salvatore Fuso, Leonello Pagano, Francesco Ciappi, Giuliano Pistelli, Riccardo |
| Copyright Year | 2000 |
| Abstract | The aim of this study was to analyse the correlates of reduced bone mineral density in patients with chronic obstructive pulmonary disease (COPD), with special regard to a possible protective role of hypercapnia. One hundred and four consecutive COPD inpatients in stabilized respiratory conditions underwent a comprehensive assessment of their health status. Bone mineral density was measured by X-ray absorptiometry at the lumbar site and at the femoral neck site. Differences in health-related variables between patients with (group O, n=62) and without (group N, n=42) lumbar and/or femoral neck osteoporosis were assessed first by univariate analysis and then by logistic regression analysis aimed to identify independent correlates of osteoporosis. Group O was characterized by worse nutritional status, as reflected by indices exploring either lean or fat mass, and by a trend towards lower forced expiratory volume in 1 sec/forced vital capacity ratio. Arterial tension of carbon dioxide lacked any correlation with bone mineral density. According to the logistic regression analysis, body mass index < or = 22 kg m(-2) qualified as the only and positive independent correlate of osteoporosis (odds ratio=4.18; 95% confidence intervals=1.19-14.71). In conclusion, malnutrition characterizes COPD patients with osteoporosis, while mild to moderate hypercapnia lacks either a positive or negative effect on bone mineral density. Longitudinal studies are needed to identify predictors rather than correlates of bone mineral density. |
| Starting Page | 23 |
| Ending Page | 28 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82792856.pdf |
| PubMed reference number | 11127495v1 |
| Volume Number | 94 |
| Issue Number | 11 |
| Journal | Respiratory medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body mass index Bone Mineral Density Test Carbon Dioxide Chronic Obstructive Airway Disease Expiration, function Forced expiratory volume procedure Head and Neck Neoplasms Lung Diseases, Obstructive Lung diseases Malnutrition Osteoporosis Patients Plain x-ray Platelet Glycoprotein 4, human Regression Analysis Structure of neck of femur Tension inpatient |
| Content Type | Text |
| Resource Type | Article |
