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Ventilatory capacity and risk for dementia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Schaub, Rainer Münzberg, Heike Borchelt, M. Nieczaj, Rolf Hillen, T. Reischies, Friedel Martin Schlattmann, Peter Geiselmann, Bernhard Steinhagen-Thiessen, Elisabeth |
| Copyright Year | 2000 |
| Abstract | BACKGROUND Previous studies have found a relationship between single indicators of ventilatory capacity and measures of cognitive function, but have not addressed dementia specifically. This study examined the relationship between different indicators of ventilatory capacity and dementia, diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition, controlling for important confounding factors. METHODS Cross-sectional data on participants (n = 437) of the Berlin Aging Study (BASE), which are representative of former West Berlin's living population aged 70 years and older, were analyzed. Ventilatory capacity was measured by spirometry as peak expiratory flow rate (PEF-R), forced expiratory volume in 1 second (FEV-1), maximal expiratory flow at 50% of forced vital capacity (MEF50%FVC), and maximal expiratory flow at 25% of forced vital capacity (MEF25%FVC). Odds ratios (OR) for dementia associated with ventilatory capacity were obtained by logistic regression, adjusting for age, gender, education, ApoE4 status, chronic obstructive pulmonary disease, smoking, heart failure, visual and auditory functioning, grip strength, and former physical activity. RESULTS Separate analyses for PEF-R, FEV-1, MEF50%FVC, and MEF25%FVC revealed significantly increased odds for dementia among subjects in the lowest compared with the best functioning group in ventilatory testing. The OR associated with PEF-R > or = 2 l/s was found to be 20.4 (confidence interval [CI] 5.1-82.7). For FEV-1, MEF50%FVC, and MEF25%FVC ORs of 7.5 (CI 2.1-27.9), 4.3 (CI 1.5-12.5), and 4.7 (CI 1.3-17) were obtained, respectively. CONCLUSIONS Ventilatory capacity, measured by spirometry in a representative sample of very elderly people, is cross-sectionally related to dementia. Taking evidence from longitudinal studies into account, this result suggests that decreased respiratory function may increase the risk for dementia, independent from already known risk factors. |
| Starting Page | 263 |
| Ending Page | 268 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
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| Alternate Webpage(s) | https://watermark.silverchair.com/M677.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAkswggJHBgkqhkiG9w0BBwagggI4MIICNAIBADCCAi0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMxrWU35C3WvPlcauXAgEQgIIB_uSyPI3LPQMLJvlRdJ1nUFtqWIcM7e1u5Tz8pn1vVmABcObjR9D0vfO1pWWXEGfiy5D9lTrsP9yULwG_KkJP1GxCx9JUrpmxcg3NMz0lnrRdGRBChGXUgR5HtedyHrN8SYzyehO0-ZC_g1rBPjQ6b3GuTC6LzXAWcKJVpvwI9DzUlrZDJj0FyXTgksJOKfHHgja8q-wFavbXp3lrbMFcT7aBPR589UhKljN5MmA5lpm52l2VvwSz6daDhwM37p9NbNC-Wt5lf6cCzFBfo_RR_PfShuH5iuY9H4PDW8Zw4Z1rN35TbTwPUp-RhQINVUNzq6y8YSEWRJHnd44a8gVyDveSRLsfoZhTyYRGTlS9OfA0O2FXEGclofR-Z77R55wy3BCNzrr1iiDfwF3uTz1E4_1SrpnmjkJp9w7iviPEm5WQvhkM1bxwCJc9ClJVLRJIdOixtTMuSglttB5Dibfc8yD6GtxyQAOhpUmcFwNhCcALccmAR3QqBmSr7ZGbs7yE7Vjzq_mAhHYkTMcJFCg5153UXABNJHgXqxECgAbO6I4zIWUe4ywLepgYgaaTemcoKRlUyOPbVHLbgkrQtsEKBN6SNce6GKtqP2cBBgeXIEn7n1Mw-O0yLArfl8SOzpXJLZK-JYqAGmhrhIktW87NPa2RwrTrbezOixexzjH38A |
| PubMed reference number | 11078098v1 |
| Volume Number | 55 |
| Issue Number | 11 |
| Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apolipoprotein E4 Chronic Obstructive Airway Disease Confidence Intervals Dementia Exercise Expiration, function Forced expiratory volume function Health Status Indicators Heart failure Lung Diseases, Obstructive Lung diseases Odds Ratio Peak expiratory flow rate measurement Pefloxacin Pulmonary Function Test/Forced Expiratory Volume 1 Spirometry Temporomandibular Joint Disorders liter/second peak expiratory flow (procedure) |
| Content Type | Text |
| Resource Type | Article |
