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Alterations in calmodulin content in fractions of rat hippocampal slices during tetanic- and calcium-induced long-term potentiation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Popov, Nikolai Reymann, Klaus G. Schulzeck, Karin Schulzeck, S. Matthies, Hansjuergen |
| Copyright Year | 1988 |
| Abstract | The content of cytosolic and membrane-bound calmodulin was radioimmunologically determined in fractions of rat hippocampal slices 5 min to 7 hours after long-term potentiation (LTP) had been induced by tetanization or exposure of slices to 4 mM Ca++. In light of concepts presuming multistage dynamics in LTP development as reflecting different cellular mechanisms, similar patterns of calmodulin alterations were observed with both models: The alterations in calmodulin content occurred during the early phase(s) of LTP development and continued for two and one hours during tetanic- and calcium-induced LTP, respectively. Thus, 5-30 min after LTP elicitation, membrane-bound calmodulin increased while cytosolic calmodulin diminished and, inversely, 30 min later an increase in cytosolic and decrease in membrane-bound calmodulin were observed. Consequently, the present results indicate that calmodulin was involved in the early phases(s) of LTP development in terms of a two-step translocation sequence. Hence, calmodulin translocation within both intracellular compartments may reflect the involvement of Ca++-calmodulin-dependent intraneuronal metabolic processes which might induce and/or temporarily maintain neuronal functional changes occurring immediately after repeated or intense stimulation of synaptic functions. |
| Starting Page | 201 |
| Ending Page | 206 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0361-9230(88)90232-8 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0361923088902328 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0361923088902328?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 3191406 |
| Alternate Webpage(s) | https://doi.org/10.1016/0361-9230%2888%2990232-8 |
| Journal | Medline |
| Volume Number | 21 |
| Journal | Brain Research Bulletin |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
