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Sleep deprivation impairs long-term potentiation in rat hippocampal slices.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Campbell, Ian G. Guinan, Michael J. Horowitz, John M. |
| Copyright Year | 2002 |
| Abstract | To determine if 12-h sleep deprivation disrupts neural plasticity, we compared long-term potentiation (LTP) in five sleep-deprived and five control rats. Thirty minutes after tetanus population spike amplitude increased 101 +/- 15% in 16 slices from sleep deprived rats and 139 +/- 14% in 14 slices from control rats. This significant (P < 0.05) reduction of LTP, the first demonstration that the sleep deprivation protocol impairs plasticity in adult rats, may be due to several factors. Reduced LTP may indicate that sleep provides a period of recuperation for cellular processes underlying neural plasticity. Alternatively, the stress of sleep deprivation, as indicated by elevated blood corticosterone levels, or other non-sleep-specific factors of deprivation may contribute to the LTP reduction. |
| File Format | PDF HTM / HTML |
| DOI | 10.1152/jn.2002.88.2.1073 |
| Alternate Webpage(s) | http://jn.physiology.org/content/jn/88/2/1073.full.pdf |
| PubMed reference number | 12163556 |
| Alternate Webpage(s) | https://doi.org/10.1152/jn.2002.88.2.1073 |
| Journal | Medline |
| Volume Number | 88 |
| Issue Number | 2 |
| Journal | Journal of neurophysiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
