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Efficient Synthesis of Various Secondary Amines Through a Titanium(IV) isopropoxide-Mediated Reductive Amination of Ketones
| Content Provider | Semantic Scholar |
|---|---|
| Author | Salmi, Chanaz Letourneux, Yves Brunel, Jean Michel |
| Copyright Year | 2006 |
| Abstract | An efficient method for the synthesis of various secondary amines through a titanium(IV)isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and amines were involved leading to the expected products in moderate to excellent yields up to 98% in numerous cases. The mechanistic rationale of this reaction has been demonstrated through 1 H and 13 C NMR experiments and occurs exclusively via the formation of a transient imine species. |
| Starting Page | 396 |
| Ending Page | 401 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.2174/157017806776611845 |
| Volume Number | 3 |
| Alternate Webpage(s) | http://aether.cmi.ua.ac.be/artikels/MB_11907.pdf |
| Alternate Webpage(s) | https://doi.org/10.2174/157017806776611845 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |