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One-Pot Parallel Synthesis Approach to Secondary Amines Based on the Reductive Amination of Ketones
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bogolubsky, Andrey V. Moroz, Yurii S. Pipko, Sergey E. Panov, Dmitriy M. Konovets, Anzhelika I. Doroschuk, Roman O. Tolmachev, Andrey A. |
| Copyright Year | 2014 |
| Abstract | A combination of a condensation mixture [a Lewis acid, Ti(Oi-Pr)4, and a water scavenger, 1-(trimethylsilyl)-2-pyrrolidinone] and a simple reductant (NaBH4) provides an efficient one-pot approach to parallel synthesis of secondary amines by the reductive amination of ketones. The approach demonstrated its applicability to a variety of substrates with different degree of hindrance of an amino or a carbonyl group affording products in moderate to high yields. |
| Starting Page | 1765 |
| Ending Page | 1772 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1055/s-0033-1341226 |
| Volume Number | 46 |
| Alternate Webpage(s) | https://www.thieme-connect.de/media/synthesis/201413/supmat/sup_ss-2014-z0090-op_10-1055_s-0033-1341226.pdf |
| Alternate Webpage(s) | https://doi.org/10.1055/s-0033-1341226 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |