NDLI: Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons.

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Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons.

Content Provider	Semantic Scholar
Author	Gong, Neng Chen, Lin Xu, Tian-Le
Copyright Year	2005
Abstract	Sodium salicylate is one of the nonsteroidal antiinflammatory drugs and is clinically used for antiinflammation and chronic pain relief. In the present study, we investigated the actions of sodium salicylate on gamma-aminobutyric acid type A receptor (GABA(A)) current in cultured rat spinal dorsal horn neurons. Sodium salicylate was found to reduce GABA(A) current in a reversible and concentration-dependent manner, but did not change its ion selectivity. Sodium salicylate was effective only when GABA and sodium salicylate were applied together. Application of sodium salicylate immediately before, but not during, the application of GABA did not result in a significant reduction of GABA(A) current. Our results demonstrate that sodium salicylate reversibly attenuates the GABA(A) response of dorsal horn neurons, suggesting that GABA(A) receptors in the region are pharmacological targets of sodium salicylate.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ir.sibs.ac.cn/bitstream/331001/1902/2/00001756-200505310-00007.pdf
PubMed reference number	15891576v1
Volume Number	16
Issue Number	8
Journal	Neuroreport
Language	English
Access Restriction	Open
Subject Keyword	Aminobutyric Acid Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Chronic pain Iontophoresis Pain relief Pharmacology Posterior Horn Cells Sodium Salicylate Structure of posterior gray horn of spinal cord gamma-Aminobutyric Acid
Content Type	Text
Resource Type	Article

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