NDLI: l characteristics , biocompatibility , and MRI applicability of novel monodisperse PEG-modi fi ed magnetic Fe 3 O 4 & SiO 2 core

Please wait, while we are loading the content...

l characteristics , biocompatibility , and MRI applicability of novel monodisperse PEG-modi fi ed magnetic Fe 3 O 4 & SiO 2 core – shell nanoparticles †

Content Provider	Semantic Scholar
Author	Kostiv, Uliana Patsula, Vitalii Šlouf, Miroslav Pongrac, Igor M. Skokic, Sinisa Radmilović, Marina Dobrivojević Pavičić, Ivan Vrček, Ivana Vinković Srećko Gajovićb Horák, Daniel
Copyright Year	2017
Abstract	Monodisperse, superparamagnetic oleic acid-stabilized Fe3O4 nanoparticles of different sizes were prepared by thermal decomposition of Fe(III) oleate. The particles were subsequently coated by silica shells of different thicknesses (yielding Fe3O4&SiO2) using a water-in-oil (w/o) reverse microemulsion technique and/or were decorated with amino groups by reaction with (3-aminopropyl)triethoxysilane. The resulting Fe3O4&SiO2-NH2 nanoparticles were then modified with poly(ethylene glycol) (PEG) via reaction with its succinimidyl ester yielding Fe3O4&SiO2-PEG particles. The in vitro biocompatibility and biosafety of the Fe3O4&SiO2 and Fe3O4&SiO2-PEG particles were investigated in a murine neural stem cell model in terms of oxidative stress response and cell viability, proliferation, and uptake. Finally, the potential of both nanoparticle types for application in magnetic resonance imaging (MRI) visualization was evaluated.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2017/ra/c7ra00224f
Alternate Webpage(s)	https://pubs.rsc.org/-/content/articlepdf/2017/ra/c7ra00224f
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in