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Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Meadows, Helen J. Harries, Mark H. Thompson, Marc Benham, Christopher D. |
| Copyright Year | 1997 |
| Abstract | 1. 4-Amino-7-hydroxy-2-methyl-5,6,7,8,-tetrahydrobenzo[b]thieno[2,3-b]pyrid ine-3-carboxylic acid, but-2-ynyl ester (SB-205384) and other gamma-aminobutyric acid(A) (GABA(A)) receptor modulators were tested for their effects on GABA-activated chloride currents in rat cerebellar granule cells by use of the whole-cell patch clamp technique. 2. The major effect of SB-205384 on GABA(A)-activated current was an increase in the half-life of decay of the response once the agonist had been removed. This is in contrast to many GABA(A) receptor modulators that have previously been shown to potentiate GABA-activated currents. 3. This profile could be explained if SB-205384 stabilizes the channel in open and desensitized states so that channel closing is dramatically slowed. Such a modulatory profile may produce a novel behavioural profile in vivo. |
| File Format | PDF HTM / HTML |
| DOI | 10.1038/sj.bjp.0701251 |
| PubMed reference number | 9257911 |
| Journal | Medline |
| Volume Number | 121 |
| Issue Number | 7 |
| Alternate Webpage(s) | http://electronicsandbooks.com/eab1/manual/Magazine/B/British%20Journal%20of%20Pharmacology%20UK/1997%20v.120-122/121_07%20(1241-1505)/1334-1338.pdf |
| Alternate Webpage(s) | http://pubmedcentralcanada.ca/pmcc/articles/PMC1564816/pdf/121-0701251a.pdf |
| Journal | British journal of pharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
