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Massive transfusion of reconstituted whole blood is well tolerated in pediatric burn surgery.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Desai, Mayuri |
| Copyright Year | 1999 |
| Abstract | BACKGROUND Massive transfusions can produce cardiovascular instability, metabolic abnormalities, dilutional coagulopathy, and pulmonary dysfunction. They also have been related to a higher incidence of infections. The purpose of this study was to assess the safety of massive transfusion of reconstituted whole blood. METHODS Twenty consecutive severely burned pediatric patients underwent near-total burn excision on admission and blood transfusion with reconstituted whole blood. Patients were studied for coagulopathies and postoperative complications related to massive transfusion. RESULTS Only one patient presented with postoperative bleeding related to acute renal failure. No other complications occurred. There were no septic episodes or pulmonary dysfunction. The amount of massive blood transfusion did not correlate with any laboratory or clinical disturbance. CONCLUSION Massive transfusion of reconstituted whole blood in severely burned pediatric patients is safe; it does not compromise hemostasis nor is it associated with an increased rate of septic episodes or pulmonary complications. A prospective randomized clinical trial comparing its effectiveness versus packed red cells is necessary. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.rug.nl/research/portal/files/3057976/c3.pdf |
| Alternate Webpage(s) | https://www.rug.nl/research/portal/files/3057976/c3.pdf |
| PubMed reference number | 10498308v1 |
| Volume Number | 47 |
| Issue Number | 3 |
| Journal | The Journal of trauma |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute kidney injury Blood Coagulation Disorders Blood Transfusion Burn injury Cardiovascular Diseases Congenital Abnormality Erythrocytes Hemostatic function Idiopathic Pulmonary Fibrosis Infection Metabolic Diseases Metabolic Process, Cellular Packed red blood cells Patients Postoperative Complications Postoperative Hemorrhage Renal Insufficiency Septic Shock Tuberculosis, Pulmonary pulmonary complications |
| Content Type | Text |
| Resource Type | Article |
