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Post-traumatic respiratory distress due to endotoxinaemia and intravascular coagulation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wardle, Elizabeth |
| Copyright Year | 1974 |
| Abstract | It has been recognized for many years that respiratory insufficiency may contribute significantly to the mortality and morbidity of patients who have suffered major trauma, burns, haemorrhage, myocard'pi infarction or sepsis. A similar condition may follow the use of cardiopulmonary bypass. There have been several recent reviews of this subject and many suggestions have been advanced as to its cause (Collins, 1969; Moss, 1972; Dowd and Jenkins, 1972). These include: bronchopneumonia, pulmonary oedema, over-transfusion, particularly with crystalloid solutions, fat embolism, endotoxinaemia, vaso-active amine release, pulmonary thromboembolism, surfactant depletion, oxygen toxicity, and pulmonary trauma. Recently attention has been concentrated upon the finHing of pulmonary microembolization (Blaisdell and Stallone, 1970; Busch et al., 1971; Mittelmayer and Sandritter, 1971). These microemboli may originate in transfused blood or reconstituted plasma, which are known to contain solid and semisolid particles such as platelet aggregates and fat droplets, or they may be a manifestation of disseminated intravascular coagulation. In the latter case platelet aggregates originating at the site of injury may be propagated to the lungs where they release vaso-active amines which may alter pulmonary vascular resistance and permeability (Blaisdell and Schlobohm, 1973; Wardle, 1973). In theory the whole picture could also be explained on the basis of endotoxinaemia. This case report describes a patient who developed the syndrome of posttraumatic respiratory insufficiency and in whom investigation revealed the presence of endotoxinaemia and intravascular coagulation. A simple but sensitive assay for the detection |
| File Format | PDF HTM / HTML |
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| PubMed reference number | 4621221v1 |
| Volume Number | 46 |
| Issue Number | 11 |
| Journal | British journal of anaesthesia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Amines Blood Coagulation Disorders Blood Platelets Bronchopneumonia Burn injury Cardiopulmonary Bypass Disseminated Intravascular Coagulation Fat embolism (disorder) Hemorrhage Idiopathic Pulmonary Fibrosis Lung Morbidity - disease rate Myocardial Infarction Oxygen Patients Platelet Glycoprotein 4, human Pulmonary Edema Pulmonary insufficiency following trauma Respiratory Insufficiency Respiratory distress Review [Publication Type] Semi-solid dose form Sepsis Thromboembolism Tuberculosis, Pulmonary crystalloid major injury |
| Content Type | Text |
| Resource Type | Article |
