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Gut Microbiota and Iron: The Crucial Actors in Health and Disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yilmaz, Bahtiyar Li, Hai |
| Copyright Year | 2018 |
| Abstract | Iron (Fe) is a highly ample metal on planet earth (~35% of the Earth's mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the most effective treatment for human beings. Notably, the excessive amount of unabsorbed iron leave unappreciated side effects at the highly interactive host⁻microbe interface of the human gastrointestinal tract. Recent advances in elucidating the molecular basis of interactions between iron and gut microbiota shed new light(s) on the health and pathogenesis of intestinal inflammatory diseases. We here aim to present the dynamic modulation of intestinal microbiota by iron availability, and conversely, the influence on dietary iron absorption in the gut. The central part of this review is intended to summarize our current understanding about the effects of luminal iron on host⁻microbe interactions in the context of human health and disease. |
| Starting Page | 105 |
| Ending Page | 122 |
| Page Count | 18 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://res.mdpi.com/pharmaceuticals/pharmaceuticals-11-00098/article_deploy/pharmaceuticals-11-00098.pdf?attachment=1&filename= |
| PubMed reference number | 30301142v1 |
| Alternate Webpage(s) | https://doi.org/10.3390/ph11040098 |
| DOI | 10.3390/ph11040098 |
| Journal | Pharmaceuticals |
| Volume Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Administration, Oral Dietary Iron Gastrointestinal Microbiome Gastrointestinal tract structure Intestinal Microbiome Iron deficiency Mammals Metals, Rare Earth Microbiota (plant) negative regulation of gut granule assembly |
| Content Type | Text |
| Resource Type | Article |
