NDLI: Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum.

Please wait, while we are loading the content...

Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum.

Content Provider	Semantic Scholar
Author	Hoen, Rob Novoa, Eva Maria López, Alba Nogueira Camacho, Noelia Cubells, Laia Vieira, Pedro Santos, Manuel Marín-García, Patricia Bautista, Jose Maria Cortés, Alfred Pouplana, Lluís Ribas De Royo, Miriam
Copyright Year	2013
Abstract	The resistance of malaria parasites to available drugs continues to grow, and this makes the need for new antimalarial therapies pressing. Aminoacyl-tRNA synthetases (ARSs) are essential enzymes and well-established antibacterial targets and so constitute a promising set of targets for the development of new antimalarials. Despite their potential as drug targets, apicoplastic ARSs remain unexplored. We have characterized the lysylation system of Plasmodium falciparum, and designed, synthesized, and tested a set of inhibitors based on the structure of the natural substrate intermediate: lysyl-adenylate. Here we demonstrate that selective inhibition of apicoplastic ARSs is feasible and describe new compounds that that specifically inhibit Plasmodium apicoplastic lysyl-tRNA synthetase and show antimalarial activities in the micromolar range.
Starting Page	499
Ending Page	509
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1002/cbic.201200620
PubMed reference number	23444099
Journal	Medline
Volume Number	14
Issue Number	4
Alternate Webpage(s)	https://www.ua.pt/ii/rnomics/ReadObject.aspx?obj=28113
Journal	Chembiochem : a European journal of chemical biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in