NDLI: The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment.

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The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment.

Content Provider	Scilit
Author	Saint-Léger, Adélaïde Sinadinos, Christopher Pouplana, Lluís Ribas De
Copyright Year	2016
Description	Journal: Bioengineered Malaria remains a major global health problem. Parasite resistance to existing drugs makes development of new antimalarials an urgency. The protein synthesis machinery is an excellent target for the development of new anti-infectives, and aminoacyl-tRNA synthetases (aaRS) have been validated as antimalarial drug targets. However, avoiding the emergence of drug resistance and improving selectivity to target aaRS in apicomplexan parasites, such as Plasmodium falciparum, remain crucial challenges. Here we discuss such issues using examples of known inhibitors of P. falciparum aaRS, namely halofuginone, cladosporin and borrelidin (inhibitors of ProRS, LysRS and ThrRS, respectively). Encouraging recent results provide useful guidelines to facilitate the development of novel drug candidates which are more potent and selective against these essential enzymes.
Related Links	http://www.tandfonline.com/doi/pdf/10.1080/21655979.2016.1149270?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879988/pdf
ISSN	21655979
e-ISSN	21655987
DOI	10.1080/21655979.2016.1149270
Journal	Bioengineered
Issue Number	2
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-03-04
Access Restriction	Open
Subject Keyword	Journal: Bioengineered Medicinal Chemistry Aminoacyl-trna Synthetase Halofuginone Plasmodium Falciparum
Content Type	Text
Subject	Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology

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