NDLI: Portal venous donor-specific transfusion in conjunction with sirolimus prolongs renal allograft survival in nonhuman primates.

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Portal venous donor-specific transfusion in conjunction with sirolimus prolongs renal allograft survival in nonhuman primates.

Content Provider	Semantic Scholar
Author	Dhanireddy, Kiran K. Bruno, David A. Weaver, Tim A. Zhang, Xun Leopardi, Frank V. Hale, Douglas A. Kirk, Allan D.
Copyright Year	2009
Abstract	Pretransplant exposure to donor antigen is known to modulate recipient alloimmunity, and frequently results in sensitization. However, donor-specific transfusion (DST) can have a protolerant effect that is dependent on route, dose and coadministered immunosuppression. Rodent studies have shown in some strain combinations that portal venous (PV) DST alone can induce tolerance, and uncontrolled clinical use of PVDST has been reported. In order to determine if pretransplant PVDST has a clinically relevant salutary effect, we studied it and the influence of concomitant immunosuppression in rhesus monkeys undergoing renal allotransplantation. Animals received PVDST with unfractionated bone marrow and/or tacrolimus or sirolimus 1 week prior to transplantation. Graft survival was assessed without any posttransplant immunosuppression. PVDST alone or in combination with tacrolimus was ineffective. However, PVDST in combination with sirolimus significantly prolonged renal allograft survival to a mean of 24 days. Preoperative sirolimus alone had no effect, and peripheral DST with sirolimus prolonged graft survival in 2/4 animals, but resulted in accelerated rejection in 2/4 animals. These data demonstrate that PVDST in combination with sirolimus delays rejection in a modest but measurable way in a rigorous model. It may thus be a preferable method for donor antigen administration.
File Format	PDF HTM / HTML
DOI	10.1111/j.1600-6143.2008.02448.x
PubMed reference number	18976300
Journal	Medline
Volume Number	9
Issue Number	1
Alternate Webpage(s)	https://open.library.emory.edu/publications/emory:txh4s/pdf/
Journal	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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