Loading...
Please wait, while we are loading the content...
Similar Documents
Immunosuppression by the JAK3 Inhibitor CP-690,550 Delays Rejection and Significantly Prolongs Kidney Allograft Survival in Nonhuman Primates
| Content Provider | Scilit |
|---|---|
| Author | Borie, Dominic C. Changelian, Paul S. Larson, Michael J. Si, Ming-Sing Paniagua, Ricardo Higgins, John P. Holm, Bari Campbell, Andrew Lau, Macy Zhang, Sally Flores, Mona G. Rousvoal, Geraldine Hawkins, Jennifer Ball, Douglas A. Kudlacz, Elizabeth M. Brissette, William H. Elliott, Eileen A. Reitz, Bruce A. Morris, Randall E. |
| Copyright Year | 2005 |
| Description | Journal: Transplantation Janus kinase 3 (JAK3) mediates signal transduction from cytokine receptors using the common chain (γc). Because mutations in genes encoding γc or JAK3 result in immunodeficiency, we investigated the potential of a rationally designed inhibitor of JAK3, CP-690,550, to prevent renal allograft rejection in nonhuman primates. Life-supporting kidney transplantations were performed between mixed leukocyte reaction-mismatched, ABO blood group-matched cynomolgus monkeys. Animals were treated with CP-690,550 (n=18) or its vehicle (controls, n=3) and were euthanized at day 90 or earlier if there was allograft rejection. Mean survival time (± standard error of mean) in animals treated with CP-690,550 (53±7 days) was significantly longer than in control animals (7±1 days, P=0.0003) and was positively correlated with exposure to the drug (r=0.79, PP CP-690,550 is the first reported JAK3 inhibitor combining efficacy and good tolerability in a preclinical model of allotransplantation in nonhuman primates and thus has interesting potential for immunosuppression in humans. |
| Related Links | http://pdfs.journals.lww.com/transplantjournal/2005/04150/Immunosuppression_by_the_JAK3_Inhibitor_CP_690,550.8.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1506696453005;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdGlb2qsojlvlytk14LkMXSEYyrbzLyphdfLL8iV9OTd6VLCt328IYYJP6fVG+pYDI;hash|cO6lwsFD3Shl/30cQdGldA== |
| Ending Page | 801 |
| Page Count | 11 |
| Starting Page | 791 |
| ISSN | 00411337 |
| e-ISSN | 15346080 |
| DOI | 10.1097/01.tp.0000157117.30290.6f |
| Journal | Transplantation |
| Issue Number | 7 |
| Volume Number | 79 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2005-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Transplantation Nonhuman Primates |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation |
