NDLI: Correlation of Hepatitis B Virus Surface Antigen Titer with Hepatitis Delta Virus Replication Level and Histological Activity in Chronic Hepatitis D B

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Correlation of Hepatitis B Virus Surface Antigen Titer with Hepatitis Delta Virus Replication Level and Histological Activity in Chronic Hepatitis D B

Content Provider	Semantic Scholar
Author	Simsek, Pinarbasi Onel, Derya Gulluoglu, M. Emin Akyuz, F. Adnan Issever, Halim Badur, Selim Demir, Kadir Alpaslan Beşişik, Fatih Ozdil, Soner Boztas, Gungor Mungan, Zeynel Kaymakoğlu, Sabahattin Tolga
Copyright Year	2018
Abstract	Chronic hepatitis delta (CHD) is a serious cause of viral hepatitis throughout the world, with high morbidity and mortality rates [1-3]. Estimates suggest that 15-20 million people worldwide have been infected by hepatitis delta virus (HDV). In Turkey, HDV remains a serious health problem, with epidemiologic studies in East and Southwest Anatolia regions showing delta super infection in 9-58% of HBV infected individuals [4]. HDV was first isolated in 1977 from the hepatocytes of hepatitis B virus (HBV) surface antigen carriers (HBsAg) as a nuclear antigen that differed from HBsAg, core (HBcAg) and e (HBeAg) antigens [5,6]. HDV is a defective virus, requiring the HBV envelope proteins, but can replicate within cells in the absence of HBV [7]. HBsAg, however, is required not only for HDV infectivity [8].but also for its packing and extracellular release [9]. Treatment of CHD is complicated by features of HDV. For example, many other viruses encode the enzymes related to their replication and development. Thus, viral replication can be inhibited by inhibiting the synthesis or activity of these enzymes. HDV, however, encodes only HDV RNA-dependent ribosome, with other enzymes involved in viral replication being cellular enzymes. Treatment of CHD should be related to the structure and life cycle of HDV and its relationships with HBV.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://biomedres.us/pdfs/BJSTR.MS.ID.000637.pdf
Language	English
Access Restriction	Open
Subject Keyword	Antigens, Nuclear Chemical and Drug Induced Liver Injury Choline Dehydrogenase, Mitochondrial DNA Replication Defective Viruses ENCODE Epidemiology Estimated HIV Hepatitis B Core Antigen Hepatitis B Surface Antigen Vaccine Hepatitis B Surface Antigens Hepatitis B Virus Hepatitis B e Antigens Hepatitis C virus Hepatitis D Infection Hepatitis D, Chronic Hepatitis Delta Virus Hepatitis, Chronic Herpesvirus 1, Cercopithecine ISO/IEC 12207 Morbidity - disease rate Murine sarcoma viruses RNA Ribosomes Self-replication Set packing Titer Viral hepatitis Virus Replication
Content Type	Text
Resource Type	Article

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