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Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bruehl, Hannah Rueger, Melanie Dziobek, Isabel Sweat, Victoria Tirsi, Aziz Javier, Elizabeth Arentoft, Alyssa Wolf, Oliver T. Convit, Antonio |
| Copyright Year | 2007 |
| Abstract | CONTEXT There is evidence of both hypothalamic-pituitary-adrenocortical (HPA) axis and cognitive dysfunction in type 2 diabetes mellitus (T2DM). However, the exact nature and the associations between these abnormalities remain unclear. OBJECTIVES The aim of the study was to characterize the nature of the HPA dysregulation in T2DM and ascertain whether impaired cognition in T2DM could be attributed to these abnormalities. DESIGN A cross-sectional study was performed, contrasting matched groups on HPA axis function and cognition by using the combined dexamethasone (DEX)/CRH test and a neuropsychological battery assessing declarative and working memory, attention, and executive function. SETTING The study was conducted in a research clinic in an academic medical center. PARTICIPANTS Participants were volunteers functioning in the cognitively normal range. We studied 30 middle-aged individuals with T2DM, on average 7.5 yr since diabetes diagnosis, and 30 age-, gender-, and education-matched controls. MAIN OUTCOME MEASURES Basal cortisol levels, cortisol levels during the DEX/CRH test, and performance on neuropsychological tests were measured. RESULTS Individuals with T2DM had elevated basal plasma cortisol levels, higher levels after DEX suppression, and a larger response to CRH (all P |
| Starting Page | 743 |
| Ending Page | 747 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.cog.psy.rub.de/papers/2007/Bruehl(2007)_J%20Clin%20Endocrinol%20Metab.pdf |
| PubMed reference number | 17426095v1 |
| Volume Number | 92 |
| Issue Number | 7 |
| Journal | The Journal of clinical endocrinology and metabolism |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Academic Medical Centers Axis vertebra Body mass index Congenital Abnormality Corticotropin Releasing Hormone Measurement Corticotropin-Releasing Hormone Dexamethasone Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Dyslipidemias Epinephrine Hemoglobin, Glycosylated Hydrocortisone Hyperactive behavior Hypertensive disease Impaired cognition Large Memory Disorders Mental association Neuropsychological Tests Pituitary Gland, Posterior TSH-Producing Pituitary Gland Carcinoma |
| Content Type | Text |
| Resource Type | Article |
