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Ataxia telangiectasia姉妹例のリンパ球成熟障害, ヘルパーT細胞の機能低下およびT細胞自己抗体の検討
| Content Provider | Semantic Scholar |
|---|---|
| Author | 玉井, 勇. 真紀子, 奥山 青木, 徹. 落合, 幸勝 |
| Copyright Year | 1986 |
| Abstract | A-T is a hereditary progressive neurodegenerative disorder that begins in early childhood. The most debilitating symptom is the progressively worsening ataxia or loss of balance. The underlying problem is a gradual and continual loss of certain types of cells in the cerebellum of the brain, which control and coordinate the movement of limbs, fingers, eyes, tongue, etc. It is thought that because the cells lack a protein namedATM (for ataxia-telangiectasia mutated), they do not recognize and repair breaks in the DNA (which carries the code for our genes). These DNA breaks occur all the time in all of us. But because the ATM protein controls over 700 other proteins that help cells to repair DNA, when there is not enoughATM protein, the DNAdamage accumulates and eventually leads to the death of individual cells, especially in the central nervous system. |
| Starting Page | 193 |
| Ending Page | 198 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.11251/ojjscn1969.18.193 |
| Volume Number | 18 |
| Alternate Webpage(s) | http://www.ataxia.org/pdf/Ataxia%20Telangiectasia.pdf |
| Alternate Webpage(s) | http://ataxia.org/pdf/Ataxia%20Telangiectasia.pdf |
| Alternate Webpage(s) | https://doi.org/10.11251/ojjscn1969.18.193 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
