NDLI: Anti-inflammatory effect of Geranium thunbergii on lipopolysaccharide-stimulated RAW 264.7 cells

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Anti-inflammatory effect of Geranium thunbergii on lipopolysaccharide-stimulated RAW 264.7 cells

Content Provider	Semantic Scholar
Author	Kwon, Tae-Hyung Kim, You-Jeong Park, Jung-Ja Kim, Tae-Wan Park, Nyun-Ho
Copyright Year	2016
Abstract	Geranium thunbergii is a perennial plant commonly used as an oriental medicine for prevention of diarrhea, constipation, and gastrointestinal disorders. However, its anti-inflammatory effect has not been evaluated thus far. Therefore, the present study aimed to investigate the anti-inflammatory effect of G. thunbergii. In this study, G. thunbergii extracted with methanol; this methanol extract was further partitioned using various solvents, and G. thunbergii ethyl acetate fraction (GTEF) was obtained. To determine the anti-inflammatory activity of G. thunbergii, the effects of GTEF on nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 cells were evaluated. GTEF suppressed NO production in a dose-dependent manner without any toxic effects. In addition, western blotting was performed to examine the effect of GTEF on expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggest that GTEF as a phytoextract may be useful for the prevention or treatment of inflammation.
Starting Page	618
Ending Page	621
Page Count	4
File Format	PDF HTM / HTML
DOI	10.9721/KJFST.2016.48.6.618
Volume Number	48
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/crosscheck/ksfst1/JAKO201608259724675.pdf
Alternate Webpage(s)	https://doi.org/10.9721/KJFST.2016.48.6.618
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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