NDLI: Remote alkylation of N-(quinolin-8-yl)benzamides with alkyl bromides via ruthenium(ii)-catalyzed C-H bond activation.

Content Provider	Semantic Scholar
Author	Mariappan, Arumugam Das, Krishna Mohan Padmanabha Jeganmohan, Masilamani
Copyright Year	2018
Abstract	A ruthenium(ii) catalyzed remote C-5 alkylation of the quinoline ring of N-(quinolin-8-yl)benzamides with alkyl bromides via C-H bond activation is described. Various substituted N-(quinolin-8-yl)benzamides reacted with tertiary or secondary or primary alkyl bromides giving the alkylated products in good to moderate yields. Herein, the ruthenium catalyzed remote C-5 alkylation is effected via aromatic C-H bond activation as a key step. It has been proved by the deuterium labelling studies and mechanistic investigations.
Starting Page	3419
Ending Page	3427
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1039/c8ob00581h
PubMed reference number	29675524
Journal	Medline
Volume Number	16
Issue Number	18
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/ob/c8ob00581h/c8ob00581h1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c8ob00581h
Journal	Organic & biomolecular chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Remote alkylation of N-(quinolin-8-yl)benzamides with alkyl bromides via ruthenium(ii)-catalyzed C-H bond activation.