NDLI: Ruthenium-Catalyzed Annulation of N-Cbz Hydrazones via C–H/N–N Bond Activation for the Rapid Synthesis of Isoquinolines

Content Provider	Semantic Scholar
Author	Deshmukh, Dewal S. Bhanage, Bhalchandra M.
Copyright Year	2019
Abstract	In this work, N-Cbz hydrazone has been employed as a rarely explored directing group for the synthesis of isoquinolines by annulation with internal alkynes via C–H/N–N activation using Ru catalyst. Additive as well as external oxidant-free rapid protocol has been established for the synthesis of isoquinolines using microwave strategy. Use of non-volatile and biodegradable PEG as a green solvent with lower catalyst loading makes the proposed protocol environmentally benign. Further, higher functional group tolerance and wide substrate scope has been observed under the stated methodology with higher yields.
Starting Page	2506
Ending Page	2514
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1055/s-0037-1611795
Volume Number	51
Alternate Webpage(s)	https://www.thieme-connect.de/media/synthesis/EFirst/supmat/sup_ss-2019-c0127-st_10-1055_s-0037-1611795.pdf
Alternate Webpage(s)	https://doi.org/10.1055/s-0037-1611795
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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