NDLI: Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.

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Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.

Content Provider	Semantic Scholar
Author	Munger, Karen A. Montero, Ana Belen Santos Fukunaga, Michiru Uda, Susumu Yura, Takeshi Imai, Enyu Kaneda, Yasufumi Valdivielso, José M. Badr, Kamal F.
Copyright Year	1999
Abstract	The human 15-lipoxygenase (15-LO) gene was transfected into rat kidneys in vivo via intra-renal arterial injection. Three days later, acute (passive) or accelerated forms of antiglomerular basement membrane antibody-mediated glomerulonephritis were induced in transfected and nontransfected or sham-transfected controls. Studies of glomerular functions (filtration and protein excretion) and ex vivo glomerular leukotriene B(4) biosynthesis at 3 hr, and up to 4 days, after induction of nephritis revealed preservation or normalization of these parameters in transfected kidneys that expressed human 15-LO mRNA and mature protein, but not in contralateral control kidneys or sham-transfected animals. The results provide in vivo-derived data supporting a direct anti-inflammatory role for 15-LO during immune-mediated tissue injury.
Starting Page	339
Ending Page	341
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/96/23/13375.full.pdf
PubMed reference number	10557328v1
Volume Number	96
Issue Number	23
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Anti-Inflammatory Agents Arachidonate 15-Lipoxygenase Basement membrane Glomerulonephritis Kidney Diseases Leukotrienes Nephritis Sacroiliitis Tissue membrane
Content Type	Text
Resource Type	Article

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