NDLI: Calcium promotes membrane association of reticulocyte 15-lipoxygenase.

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Calcium promotes membrane association of reticulocyte 15-lipoxygenase.

Content Provider	Semantic Scholar
Author	Watson, Alice L. Doherty, Frederick J.
Copyright Year	1994
Abstract	The reticulocyte 15-lipoxygenase (linoleate:oxygen oxidoreductase, EC 1.13.11.12) is implicated in oxidative damage to reticulocyte mitochondria before their elimination by degradation during maturation to the erythrocyte. A proportion of the 15-lipoxygenase sediments with the mitochondrial-rich stromal fraction of density-gradient-fractionated rabbit reticulocytes suggesting a physical association with mitochondria before their elimination. Ca2+ promotes binding of reticulocyte 15-lipoxygenase to isolated rat liver and reticulocyte mitochondria and 15-lipoxygenase-mediated lipid peroxidation of mitochondrial lipids and free linoleic acid. Association of reticulocyte 15-lipoxygenase with isolated mitochondria is not simply a consequence of Ca(2+)-induced swelling, but implies that Ca2+ mediates translocation of soluble lipoxygenase to mitochondrial membranes. Therefore, Ca2+ may have an important physiological role in the regulation of 15-lipoxygenase-mediated targeting of reticulocyte mitochondria for degradation.
Starting Page	293
Ending Page	293
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biochemj.org/content/ppbiochemj/298/2/377.full.pdf
PubMed reference number	8135744v1
Volume Number	298
Part	2
Journal	The Biochemical journal
Language	English
Access Restriction	Open
Subject Keyword	Arachidonate 15-Lipoxygenase Calcium Erythrocytes Excretory function Linoleic Acid Lip swelling Lipid Peroxidation Lipoxygenase Mitochondrial Diseases Oxygen Reticulocytes Tissue membrane linoleates
Content Type	Text
Resource Type	Article

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