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Density, Serotype Diversity, and Fitness of Streptococcus pneumoniae in Upper Respiratory Tract Cocolonization With Nontypeable Haemophilus influenzae.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lewnard, Joseph A. Huppert, Amit Givon-Lavi, Noga Pettigrew, Melinda M. Regev-Yochay, Gili Dagan, Ron Weinberger, Daniel Martin |
| Copyright Year | 2016 |
| Abstract | BACKGROUND Coinfections by Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) are frequently implicated in complex otitis media. Whereas upper respiratory tract carriage precedes disease for both pathogens, interactions between species in cocolonized hosts are poorly understood. We compared colonization densities and the diversity and fitness of pneumococcal serotypes in single-species and mixed-species colonization. METHODS We analyzed nasopharyngeal pneumococcal carriage and nasopharyngeal and oropharyngeal NTHi carriage in 13 541 samples collected over 6909 study visits from 769 children 2-30 months old in a 7-valent pneumococcal conjugate vaccine dosing trial. We measured density associations between the species and compared pneumococcal serotype diversity during and in the absence of NTHi colonization. We used logistic regression to quantify associations between NTHi colonization and previously published pneumococcal serotype factors related to fitness. RESULTS Densities of the 2 species were positively associated when they co-occur in the nasopharynx. NTHi colonization was associated with reduced pneumococcal serotype diversity among children 2-18 months old and was more prevalent among children carrying pneumococcal serotypes with greater capsular thickness, neutrophil resistance, and metabolic efficiency. CONCLUSIONS Pneumococcal-NTHi cocolonization is associated with an elevated density of both species and with reduced diversity and increased fitness of pneumococcal serotypes. NTHi colonization may create a selective environment favoring pneumococci with immune-evasive phenotypes. |
| Starting Page | 1411 |
| Ending Page | 1420 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://docs.wixstatic.com/ugd/307c28_af533a16b7f644a58dbeca5a03260d9e.pdf |
| PubMed reference number | 27540112v1 |
| Volume Number | 214 |
| Issue Number | 9 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Coinfection Ear Inflammation Hemophilus ducreyi Immunostimulating conjugate (antigen) Influenza Mental association Metabolic Process, Cellular Nasopharynx Oropharyngeal Otitis Media Phenotype Pneumonia Respiratory System Respiratory Tract Diseases Respiratory tract structure Scientific Publication Serotype Streptococcus pneumoniae Upper respiratory tract Vaccines, Conjugate density neutrophil |
| Content Type | Text |
| Resource Type | Article |
