NDLI: Oropharyngeal colonization by nontypeable Haemophilus influenzae among healthy children attending day care centers.

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Oropharyngeal colonization by nontypeable Haemophilus influenzae among healthy children attending day care centers.

Content Provider	Semantic Scholar
Author	Puig, Carmen Gil Martí, S. Salvador Fleites, A. Rodriguez Trabazo, Rafael Calatayud, Laura Linares, Juan Carlos Ardanuy, Carmen
Copyright Year	2014
Abstract	Haemophilus influenzae colonizes the upper respiratory tract and can spread causing otitis and sinusitis. This work aimed to study the oropharyngeal carriage rate in healthy <5-year-old children attending day care centers in Oviedo, Spain in two consecutive years (January to March 2004-2005). The carriage rate was 42% (400/960) and highly variable among centers (range, 12% to 83%). Isolates were mainly identified as nontypeable H. influenzae (NTHi, 99%). Epidemiologically, 127 different genotypes were identified by PFGE with a minimum of two genotypes per center. One hundred fourteen children (12%) were included in both studies and none of them harbored the same strain over a period of time. The isolates only showed resistance to cotrimoxazol and ampicillin, presenting a shift in the level of ampicillin reduced susceptibility, showing a predominance of PBP3 mutations in 2004 and a predominance of β-lactamase production in 2005. This study proved the great genetic variability of NTHi isolates that present similar genotypic patterns in both years with no long-term carriage of the same strain.
Starting Page	245
Ending Page	249
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://diposit.ub.edu/dspace/bitstream/2445/66315/1/652347.pdf
PubMed reference number	24716536v1
Alternate Webpage(s)	https://doi.org/10.1089/mdr.2013.0186
DOI	10.1089/mdr.2013.0186
Journal	Microbial drug resistance
Volume Number	20
Issue Number	5
Language	English
Access Restriction	Open
Subject Keyword	Ampicillin Chancroids Day Care, Medical Ear Inflammation Fourteen Genotype Haemophilus influenzae Ab:ACnc:Pt:Ser:Qn Influenza Mutation Ninety Nine Oropharyngeal disorders Respiratory tract structure Sinusitis Upper respiratory tract
Content Type	Text
Resource Type	Article

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