NDLI: Quantification of bursting and synchrony in cultured hippocampal neurons.

Please wait, while we are loading the content...

Quantification of bursting and synchrony in cultured hippocampal neurons.

Content Provider	Semantic Scholar
Author	Eisenman, Lawrence Emnett, Christine Marie Mohan, Jayaram Zorumski, Charles F. Mennerick, Steven J.
Copyright Year	2015
Abstract	It is widely appreciated that neuronal networks exhibit patterns of bursting and synchrony that are not captured by simple measures such as average spike rate. These patterns can encode information or represent pathological behavior such as seizures. However, methods for quantifying bursting and synchrony are not agreed upon and can be confounded with spike rate measures. Previous validation has largely relied on in silico networks and single experimental conditions. How published measures of bursting and synchrony perform when applied to biological networks of varied average spike rate and subjected to varied experimental challenges is unclear. In multielectrode array recordings of network activity, we found that two mechanistically distinct drugs, cyclothiazide and bicuculline, produced equivalent increases in average spike rate but differed in bursting and synchrony. We applied several measures of bursting to the recordings (2 threshold interval methods and a surprise-based method) and found that a measure based on an average critical interval, adjusted for the array-wide spike rate, performed best in quantifying differential drug effects. To quantify synchrony, we compared a coefficient of variation-based measure, the recently proposed spike time tiling coefficient, the SPIKE-distance measure, and a global synchrony index. The spike time tiling coefficient, the SPIKE-distance measure, and the global synchrony index all captured a difference between drugs with the best performance exhibited by the global synchrony index. In summary, our exploration should aid other investigators by highlighting strengths and limitations of current methods.
Starting Page	168
Ending Page	176
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jn.physiology.org/content/jn/114/2/1059.full.pdf
Alternate Webpage(s)	http://jn.physiology.org/content/jn/early/2015/06/01/jn.00079.2015.full.pdf
PubMed reference number	26041823v1
Alternate Webpage(s)	https://doi.org/10.1152/jn.00079.2015
DOI	10.1152/jn.00079.2015
Journal	Journal of neurophysiology
Volume Number	114
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Basal Ganglia Diseases BaseLine dental cement Behavioral tic Bicuculline Coefficient Eighty Isoelectric Point Note (document) One Thousand PENK wt Allele Quantitation RGS Proteins RS 43285-193 Scientific Publication Seizures Technetium Tellurium cisplatin/etoposide protocol cyclothiazide
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Maternal placi protein levels in early- and late-onset preeclampsia.

Megalencephaly and Macrocephaly.

Evaluation of two Vaisala RS 92 radiosonde solar radiative dry bias correction algorithms

A New Averaged Switch Model Including Conduction Losses for PWM Converters Operating in Discontinuous Inductor Current Mode

In vitro gas production measurements to evaluate interactions between untreated and chemically treated rice straws, grass hay, and mulberry leaves.

The old open clusters Berkeley 32 and King 11 ⋆

Comparison of Birth Outcomes by Gestational Diabetes Screening Criteria

Draft Genome Sequence of Lactococcus sp. Strain Rs-Y01, Isolated from the Gut of the Lower Termite Reticulitermes speratus

Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex.

Quantification of bursting and synchrony in cultured hippocampal neurons.

Similar Documents

Maternal placi protein levels in early- and late-onset preeclampsia.

Megalencephaly and Macrocephaly.

Evaluation of two Vaisala RS 92 radiosonde solar radiative dry bias correction algorithms

A New Averaged Switch Model Including Conduction Losses for PWM Converters Operating in Discontinuous Inductor Current Mode

In vitro gas production measurements to evaluate interactions between untreated and chemically treated rice straws, grass hay, and mulberry leaves.

The old open clusters Berkeley 32 and King 11 ⋆

Comparison of Birth Outcomes by Gestational Diabetes Screening Criteria

Draft Genome Sequence of Lactococcus sp. Strain Rs-Y01, Isolated from the Gut of the Lower Termite Reticulitermes speratus

Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex.

Quantification of bursting and synchrony in cultured hippocampal neurons.