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Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers
| Content Provider | Semantic Scholar |
|---|---|
| Author | Phillips, Daniel J. Patterson, Joseph P. Reilly, Rachel K. O’ Gibson, Matthew I. |
| Copyright Year | 2014 |
| Abstract | The encapsulation and selective delivery of therapeutic compounds within polymeric nanoparticles offers hope for the treatment of a variety of diseases. Traditional approaches to trigger selective cargo release typically rely on polymer degradation which is not always sensitive to the biological location of a material. In this report, we prepare nanoparticles from thermoresponsive polymers with a ‘solubility release catch’ at the chain-end. This release catch is exclusively activated in the presence of intracellular glutathione, triggering an ‘isothermal’ response and promoting a change in polymer solubility. This solubility switch leads to specific and rapid nanoparticle disassembly, release of encapsulated cargo and produces completely soluble polymeric side-products. |
| Starting Page | 126 |
| Ending Page | 131 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C3PY00991B |
| Alternate Webpage(s) | http://wrap.warwick.ac.uk/58700/1/WRAP_Gibson_Glutathione-Triggered%20Disassembly.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C3PY00991B |
| Volume Number | 5 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
