NDLI: Formulation of pH-Responsive Methacrylate-Based Polyelectrolyte-Stabilized Nanoparticles for Applications in Drug Delivery.

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Formulation of pH-Responsive Methacrylate-Based Polyelectrolyte-Stabilized Nanoparticles for Applications in Drug Delivery.

Content Provider	Europe PMC
Author	Kim, Bumjun Zhang, Dawei Armstrong, Madeleine S. Pelczer, István Prud’homme, Robert K.
Copyright Year	2022
Abstract	pH-responsive polyelectrolytes, includingmethacrylate-basedanioniccopolymers (MACs), are widely used as enteric coatings and matricesin oral drug delivery. Despite their widespread use in these macroscopicapplications, the molecular understanding of their use as stabilizersfor nanoparticles (NPs) is lacking. Here, we investigate how MACscan be used to create NPs for therapeutic drug delivery and the roleof MAC molecular properties on the assembly of NPs via flash nanoprecipitation.The NP size is tuned from 59 to 454 nm by changing the degree of neutralization,ionic strength, total mass concentration, and the core-to-MAC ratio.The NP size is determined by the volume of hydrophilic domains onthe surface relative to the volume of hydrophobic domains in the core.We calculate the dimensions of the hydrophobic NP core relative tothe thickness of the polyelectrolyte layer over a range of ionizations.Importantly, the results are shown to apply to both high-molecular-weightpolymers as core materials and small-molecule drugs. The pH responsivenessof MAC-stabilized NPs is also demonstrated. Future development ofpolyelectrolyte copolymer-stabilized nanomedicines will benefit fromthe guiding principles established in this study.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9791616&blobtype=pdf
Journal	ACS Applied Nano Materials [ACS Appl Nano Mater]
Volume Number	5
DOI	10.1021/acsanm.2c04539
PubMed Central reference number	PMC9791616
Issue Number	12
PubMed reference number	36583123
e-ISSN	25740970
Language	English
Publisher	American Chemical Society
Publisher Date	2022-11-24
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2022 The Authors. Published by American Chemical Society
Subject Keyword	flash nanoprecipitation nanoparticles enteric-coatingpolymers pH-responsive polymers polyelectrolytes methacrylate-based copolymers drug delivery Eudragit
Content Type	Text
Resource Type	Article
Subject	Materials Science

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