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Evaluation of Some immunological and biochemical parameters as markers in the early diagnosis of diabetic nephropathy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Al-Fatlawi, Rawaa Behlul Al-Yaqoobi, Kifah Jabbar Alsadawi, Ameera A. Hadi, Najah R. Ghaly, Kareem Shukur, Wasan Hamid |
| Copyright Year | 2019 |
| Abstract | The Diabetic Nephropathy(DN) is the major reasons for ESRD in the most common around the world as a result of the rising in the prevalence of obesity and T2DM.The death rate of DN patients having dialysis during 1-5 years is higher than non-diabetic according to the high danger of cardiovascular and infectious diseases. The diagnosis and follow-up of the aggravation of diabetic nephropathy is critical in reducing mortality from this disease. The present study was designed to exam some immunological and biochemical parameters in the early diagnosis of diabetic nephropathy. Four hundred T2DM patients were enrolled, and their age range was 39-60 with a mean± SD of 49.4±10.1 years, they were referred to the Department of diabetic (Alasdair Teaching Hospital) during the period October-2017 to October-2018 for treatment. According to the level of Albuminuria the patients were distributed into three clinical groups to normal Albuminuria (n=145), microalbuminuria (n=162), and macro Albuminuria (n=93) groups. The whole blood of all the patients was withdrawn. The plasma of all patients were tested for HBA1C, Creatinine, Urea, albumin concentration by spectrophotometer, and ICAM-1, TNF-α, IL-1β,IL-6, HMGB1concentration by ELISA technique. The study included the Creatinine values were significantly higher in macro Albuminuria compared with Micro Albuminuria and normoalbuminuria (1.3±0.8) versus (0.9±0.2), (1.0±0.2) respectively. Urea values were significantly higher in Macro Albuminuria and Micro Albuminuria (59.5±14.5), (62.4±22.1). IL-1β values were significantly higher in Micro Albuminuria compared with Macro Albuminuria and Control (43.2±18.8) versus (34.3±25.4), (31.7±19.8) respectively . ICAM-1Avalues were significantly higher in Micro Albuminuria compared with Macro Albuminuria and Control (62.67±5.6), (46.7±5.9),(41.93±5.8), respectively. |
| Starting Page | 28 |
| Ending Page | 33 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.36295/asro.2019.22074 |
| Volume Number | 22 |
| Alternate Webpage(s) | https://www.journal.atmph-specialissues.org/uploads/179/6611_pdf.pdf |
| Alternate Webpage(s) | https://doi.org/10.36295/asro.2019.22074 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
