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In Vitro Study of Self Emulsifying Drug Delivery System of Poorly Water Soluble Drug Spironolactone
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dewan, Irin Gaji, Mahjabeen Shahriar, Mohammad Islam, S. M. Ashraful |
| Copyright Year | 2012 |
| Abstract | The main objective of study was to formulate SEDDS of Spironolactone in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. SEDDS are isotropic mixtures of oils and surfactants, sometimes containing cosolvents. The present research work describes a Self Emulsifying Drug Delivery System (SEDDS) of Spironolactone using oils (Arachise oil, Oleic Acid, Castor oil, Soyabean Oil, Neobee M5, Migloyol, Capmul), surfactants (Tween-80, Cremophor RH40,Cremophor EL) and adsorbents (Aerosil-200,Avicel PH101,Lactose, Dextrose, Mannitol and Talc). In case of SEEDS of Spironolactone, the release rates of all oils were very rapid in Avicel PH101(above 82%) because it has the best flow property among the other absorbents. It Self Emulsifying Drug Delivery System observed that the release pattern from Arachis oil (92.95%), Oleic acid (90.21%) and Castor oil (97.54%) were better in comparison to other oils. Besides, it can be comprehend that the release rate of the three oils were very rapid in Tween-80(above 85%) because it has the best emulsifying property than Cremophor RH40 and Cremophor EL. Besides the solubility of Spironolactone in various oils was determined to identify the oil phase of SEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. The formulation was found to show a significant improvement in terms of the drug release with complete release of drug within 60 minutes. Thus, Self microemulsifying formulation of Spironolactone was successfully developed. INTRODUCTION: Self-emulsifying drug delivery systems (SEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SEDDSs are isotropic mixtures of oils and surfactants, sometimes containing co-solvents, and can be used for the design of formulations in order to improve the oral absorption of highly lipophilic compounds . SEDDSs emulsify spontaneously to produce fine oil-in-water emulsions when introduced into an aqueous phase under gentle agitation SEDDS can be orally administered in soft or hard gelatin capsules and form fine, relatively stable oil-in-water emulsions upon aqueous dilution. In recent years, the formulation of poorly soluble compounds presented interesting challenges for formulation scientists in the pharmaceutical industry. Up to 40% of new chemical entities discovered by the pharmaceutical industry are poorly soluble or lipophilic compounds, which leads to poor oral bioavailability, high intra and inter subject variability, and lack of dose proportionality. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ijpsr.com/V3I3/37%20Vol.%203,%20Issue%203,%202012,%20IJPSR-1116,%20Paper%2037.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
