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Formulation and Evaluation of Self Micro Emulsifying Drug Delivery System for Poorly Water Soluble Drug Risperidone
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pimple, Smita S. Chaudhari, Pravin Digamber |
| Copyright Year | 2013 |
| Abstract | To enhance the solubility and dissolution of poorly water soluble drug Risperidone (RIS), Self-micro emulsifying drug delivery system (SMEDDS) was developed and evaluated. Solubility study, emulsification ability, ternary phase diagrams and central composite design (CCD) were used as primary tools to select the components of the system and optimize the composition of liquid RISSMEDDS. Liquid RIS-SMEDDS was formulated using Capryol90 as oil, Cremophor EL and Transcutol P as surfactant and co-surfactant respectively. The liquid RIS-SMEDDS (with globule size 35.68±4nm, transmittance 97.40% and self-emulsification time 35 sec.) optimized formulation (F3) containing Capryol 90 (22.93%), Cremophor EL (56.29%) and Transcutol P (20.78%) was spray dried using Aerosil 200 as an inert solid carrier. The SEM analysis, DSC and XRD spectra reveal the presence of RIS in molecular state in solid SMEDDS. The in vitro dissolution study indicates improved dissolution characteristics with higher percent drug release for solid SMEDDS (92.30%) compared to marketed preparation (80.48%). In conclusion, SMEDDS for RIS holds promise to be developed as potential system for improved oral delivery. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://globalresearchonline.net/journalcontents/v23-1/31.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
