Loading...
Please wait, while we are loading the content...
Similar Documents
Alternatives to traditional first-line antihypertensive treatment: unresolved questions and therapeutic dilemmas. A personal approach.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zusman, Randall M. |
| Copyright Year | 1989 |
| Abstract | The best antihypertensive regimen for use in patients with mild-to-moderate hypertension has not been determined. When nonpharmacological treatment of hypertension fails, initial drug treatment with diuretic drugs, sympatholytic agents (including beta-adrenergic receptor blockers), or vasodilators will result in satisfactory blood pressure control. However, each of these therapies has effects that are independent of their antihypertensive activity and that should be considered before a selection is made for initial therapy. The adverse effects of diuretic agents and beta-adrenergic receptor-blocking drugs on plasma lipid profiles may diminish the beneficial effects of blood pressure reduction. On the other hand, the hypocholesterolemic effect of alpha-adrenergic receptor antagonists, the potential cardioprotective effect of angiotensin converting enzyme inhibitors, and the salutary effects of calcium channel blockers on left ventricular function are responses that would support the use of vasodilatory therapy. Vasodilating antihypertensive drugs may be more beneficial than "standard" therapy and should be considered for the initial treatment of newly diagnosed hypertensive patients. |
| Starting Page | 4565 |
| Ending Page | 4582 |
| Page Count | 18 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/13/5_Suppl/I154.full.pdf?download=true |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/13/5_Suppl/I154.full.pdf |
| PubMed reference number | 2490819v1 |
| Volume Number | 13 |
| Issue Number | 5 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenergic Antagonists Adrenergic Receptor Angiotensin-Converting Enzyme Inhibitors Angiotensins Antihypertensive Agents Calcium Channel Blockers Diuretics Heart Ventricle Hypertensive disease Left Ventricular Function Patients Sympatholytics Vasodilator Agents alpha-adrenergic receptor beta-2 Adrenergic Receptors |
| Content Type | Text |
| Resource Type | Article |
