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Traditional first-line therapy. Overview of medical benefits and side effects.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gifford, Ray W. Borazanian, R. A. |
| Copyright Year | 1989 |
| Abstract | When diuretic-based stepped care was first advocated for the treatment of hypertension, there were fewer classes of antihypertensive medication than there are today. In 1984, the third Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC) for the first time suggested an alternative initial treatment with a beta-blocker in selected hypertensive patients, and the fourth JNC report has recommended the alternatives of calcium channel blockers or angiotensin converting enzyme inhibitors for step-one therapy as well. However, only the diuretic drugs and beta-blockers have been shown to reduce cardiovascular morbidity and mortality in prospective, long-term, controlled trials. Moreover, 30 years' experience with diuretic agents and 20 years' experience with beta-blockers have defined the advantages, disadvantages, and potential side effects of these drugs more precisely than is possible for newer agents. The diuretic drugs and beta-blockers remain excellent choices in the management of hypertension. |
| Starting Page | 428 |
| Ending Page | 435 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/13/5_Suppl/I119.full.pdf |
| PubMed reference number | 2577456v1 |
| Volume Number | 13 |
| Issue Number | 5 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Angiotensins Antihypertensive Agents Calcium Channel Blockers Choice Behavior Diuretics Hypertensive disease Morbidity - disease rate Patients benefit |
| Content Type | Text |
| Resource Type | Article |
