NDLI: Prognostic value of tumor-infiltrating Foxp3+ regulatory T cells in patients with breast cancer: a meta-analysis

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Prognostic value of tumor-infiltrating Foxp3+ regulatory T cells in patients with breast cancer: a meta-analysis

Content Provider	Semantic Scholar
Author	Zhou, Yu Shao, Nan Aierken, Nijiati Xie, Chuanbo Ye, Runyi Qian, Xueke Hu, Ziye Zhang, Jin Lin, Ying
Copyright Year	2017
Abstract	PURPOSE The prognostic value of tumor-infiltrating Foxp3+ regulatory T cells (Tregs) in breast cancer remains controversial. Therefore, we performed this meta-analysis to determine the impact of Foxp3+ Tregs infiltration on survival outcomes. METHODS Relevant literature was retrieved from Pubmed, Web of science and Cocohrane until May 30, 2016. Meta-analysis was performed using hazard ratios (HRs), odds ratio (OR) and 95 % confidence intervals (CI) as effect measures. RESULTS Fourteen studies (10,259 patients) were included. Meta-analysis showed that high Foxp3+ Tregs infiltration was correlated with high histological grade (OR= 2.96, 95%CI [2.03-4.31]), estrogen receptor (ER) negativity (OR= 0.38, 95%CI [0.23-0.60]), human epidermal growth factor receptor type 2 (HER2) positivity (OR=2.43, 95%CI [1.69-3.51]). The detection of FOXP3+ Tregs was significantly associated with recurrence-free survival (RFS) of patients (HR = 1.58, 95 % CI [1.03-2.44]). CONCLUSION Our meta-analysis suggests that high Foxp3+ Tregs infiltration is associated with poor RFS in breast cancer patients and predicts histological grade, estrogen receptor and HER-2 status.
Starting Page	4098
Ending Page	4105
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jcancer.org/v08p4098.pdf
PubMed reference number	29187886v1
Alternate Webpage(s)	https://doi.org/10.7150/jca.21030
DOI	10.7150/jca.21030
Journal	Journal of Cancer
Volume Number	8
Language	English
Access Restriction	Open
Subject Keyword	Adult Fanconi syndrome Confidence Intervals Epidermal Growth Factor Receptor Estrogen Receptors Estrogens Growth Factor Receptors Infiltration Mammary Neoplasms Odds Ratio Patients erbB-2 Receptor estrogen receptor alpha, human
Content Type	Text
Resource Type	Article

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