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Correlation of Hormone Receptor and Human Epidermal Growth Factor Receptor-2/neu Expression in Breast Cancer with Various Clinicopathologic Factors
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bansal, Cherry Sharma, Aarti E. Pujani, Mukta Pujani, Meenu Sharma, Kiran L. Srivastava, Ambey Kumar Singh, Urwashi |
| Copyright Year | 2017 |
| Abstract | Background A significant development in the breast carcinoma management is the correlation between the presence of hormone receptors in the tumor and response to hormonal therapy and chemotherapy. Human epidermal growth factor receptor-2/neu (Her-2/neu) overexpression also serves as a very useful parameter to predict response to herceptin. Aim of Study The study was conducted to correlate immunohistochemical expression of markers such as estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu with various clinicopathologic parameters. Materials and Methods The study included 509 cases of breast carcinoma over a period of 5 years (from May 2009 to May 2014). Immunohistochemistry (IHC) for ER, PR, and her-2/neu was performed. Results ER positivity was observed in 42.8% (218/509) cases, PR positivity in 31.8% (194/509) cases whereas her-2 neu positivity was seen in 40.7% (203/509) cases. Triple marker (ER, PR, and Her-2/neu) negative cases were 23.6% (120/509) cases. ER and PR expression was found to have a statistically significant correlation with tumor grade. Statistically significant correlation was observed between tumor size and tumor grade and her-2/neu expression. Her-2/neu expression showed statistically significant association with tumor stage. As the tumor grade increased, the proportion of triple-negative cases went on increasing, which was statistically significant. Conclusion IHC has an increasingly important prognostic role in determination of factors that affect clinicopathologic features. Nevertheless, the results of this large series showed different patterns of findings with respect to clinicopathologic features. |
| Starting Page | 483 |
| Ending Page | 489 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29333017v1 |
| Alternate Webpage(s) | https://doi.org/10.4103/ijmpo.ijmpo_98_16 |
| DOI | 10.4103/ijmpo.ijmpo_98_16 |
| Journal | Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology |
| Volume Number | 38 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Breast Carcinoma ERBB2 protein, human Epidermal Growth Factor Receptor Estrogen Receptors Estrogens Gonadorelin Herceptin Hormone Therapy Immunohistochemistry Mammary Neoplasms Oncogene ErbB2 Population Parameter Receptors, Progesterone Tumor stage estrogen receptor alpha, human |
| Content Type | Text |
| Resource Type | Article |
