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Transient aerodynamic atomisation model to predict aerosol droplet size of pressurised metered dose inhalers (pMDI)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gavtash, Barzin Versteeg, Hendrik K. Hargrave, Graham K. Myatt, Benjamin J. Lewis, David Allen Church, Tanya Brambilla, Gaetano |
| Copyright Year | 2017 |
| Abstract | ABSTRACTPressurized metered dose inhalers (pMDI) produce large numbers of droplets with smaller sizes than 5 μm to treat asthma and other pulmonary diseases. The mechanism responsible for droplet generation from bulk propellant liquid is poorly understood, mainly because the small length scales and short time scales make it difficult to characterize transient spray formation events. This article describes the development and findings of a numerical atomization model to predict droplet size of pharmaceutical propellants from first principles. In this model, the velocity difference between propellant vapor and liquid phase inside spray orifice leads to formation of wave-like instabilities on the liquid surface. Two variants of the aerodynamic atomization model are presented based on assumed liquid precursor geometry: (1) cylindrical jet-shaped liquid ligaments surrounded by vapor annulus; (2) annular liquid film with vapor flow in the core. The growth of instabilities on the liquid precursor surfaces and th... |
| Starting Page | 998 |
| Ending Page | 1008 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1080/02786826.2017.1327121 |
| Alternate Webpage(s) | https://dspace.lboro.ac.uk/dspace-jspui/bitstream/2134/24980/3/Transient%20aerodynamic%20atomization%20model%20to%20predict%20aerosol%20droplet%20size%20of%20pressurized%20metered%20dose%20inhalers%20pMDI.pdf |
| Alternate Webpage(s) | https://doi.org/10.1080/02786826.2017.1327121 |
| Volume Number | 51 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
