NDLI: A model of transient internal flow and atomization of propellant/ethanol mixtures in pressurized metered dose inhalers (pMDI)

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A model of transient internal flow and atomization of propellant/ethanol mixtures in pressurized metered dose inhalers (pMDI)

Content Provider	Semantic Scholar
Author	Gavtash, Barzin Versteeg, Hendrik K. Hargrave, Graham K. Myatt, Benjamin J. Lewis, David Allen Church, Tanya Brambilla, Gaetano
Copyright Year	2018
Abstract	ABSTRACTThis article reports the extension to binary propellant/excipient mixtures of the multiphase model of transient internal flow and atomization in pressurized metered dose inhalers (pMDIs) of Gavtash and colleagues for propellant-only flows. The work considers different accounts of the effect of less volatile ethanol on the saturated vapor pressure (SVP), viscosity and surface tension of HFA-based pMDI formulations. Representation of the SVP of HFA/ethanol mixtures by Raoult's law is compared with the empirical model developed by Gavtash and colleagues as well as different theoretical mixing rules for surface tension and viscosity. For initial ethanol contents ranging from 0 to 20% by mass, the temperature, pressure and spray velocity were predicted to be almost independent of ethanol concentration when using the empirical SVP model of Gavtash and colleagues. The predicted aerosol droplet size increases with increasing concentration of ethanol. These model predictions compare favorably with phase Do...
Starting Page	494
Ending Page	504
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1080/02786826.2018.1433814
Alternate Webpage(s)	https://dspace.lboro.ac.uk/dspace-jspui/bitstream/2134/33450/1/27762877_File000052_640131153-final.pdf
Alternate Webpage(s)	https://doi.org/10.1080/02786826.2018.1433814
Volume Number	52
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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