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Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Oskarsson, Per Lins, P. E. Ahré, B. Adamson, Ulf |
| Copyright Year | 2000 |
| Abstract | OBJECTIVE To evaluate if insulin has a suppressive effect on the glucagon secretion stimulated by arginine in type 1 diabetes. RESEARCH DESIGN AND METHODS The alpha-cell response to an i.v. bolus of arginine (150mgkg(-1)) followed by an infusion of arginine (10mgkg(-1)min(-1)) was studied in random order during either low dose infusion (LDT) or high dose infusion (HDT) of insulin in ten patients with type 1 diabetes. The blood glucose level was clamped at an arterialized level of 5mmoll(-1) by a variable infusion of glucose. Venous C-peptide, glucagon, growth hormone, and insulin were analyzed. RESULTS The mean plasma concentration of insulin was four times higher during the HDT. The C-peptide level did not differ between the LDT and the HDT. During the LDT in response to arginine the blood glucose level increased from 5.0 to 5.8mmol l(-1) although the glucose infusion was markedly reduced, while no change was seen during the HDT. A significantly smaller increase in the glucagon levels during the HDT was seen (area under the curve of 413+/-45 vs 466+/-44pgml(-1)h(-1), P=0.03) while the growth hormone levels were almost identical. CONCLUSION This study demonstrates that a high level of circulating insulin exerts an inhibitory effect on the glucagon response to arginine in type 1 diabetes. Thus, the suppressive effect of insulin on the glucagon release from the alpha-cell seems to be general and not only dependent on stimulation by hypoglycemia. |
| Starting Page | 237 |
| Ending Page | 240 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://eje.bioscientifica.com/downloadpdf/journals/eje/142/1/30.pdf |
| Alternate Webpage(s) | http://www.eje-online.org/content/142/1/30.full.pdf |
| PubMed reference number | 10633218v1 |
| Volume Number | 142 |
| Issue Number | 1 |
| Journal | European journal of endocrinology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Area Under Curve Arginine Blood Glucose Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent GCG gene Hematological Disease Impaired glucose tolerance Patients Small glucagon secretion physical hard work telbivudine |
| Content Type | Text |
| Resource Type | Article |
