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Ileal transposition rapidly improves glucose tolerance and gradually improves insulin resistance in non-obese type 2 diabetic rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhu, Hengliang Wang Zheng, Zhihai Ye, Bailiang Ruan, Xiaojiao Zheng, Xiaofeng Li, Guoxin |
| Copyright Year | 2018 |
| Abstract | Background Many studies have confirmed that ileal transposition can improve type 2 diabetes mellitus (T2DM), accompanied by increased glucagon-like peptide-1 (GLP-1). We performed the experiment on diabetic rats to evaluate the effects and mechanisms of ileal transposition on the glycemic metabolism. Methods Twenty Goto-Kakizaki (GK) rats were randomly divided into the ileal transposition group (IT group) and the sham operation group (Sham group). Weight, food intake, fasting plasma glucose (FPG), fasting insulin (F-ins), oral glucose tolerance test (OGTT) and GLP-1 were determined at baseline and 1, 4, 8, 16 and 24 weeks post-operatively. The homeostasis model assessment-insulin resistance (HOMA-IR) index and the area under the curve (AUC) during OGTT were measured. Histological determination of the GLP-1 receptor (GLP-1R) was performed on the pancreas and ileum 24 weeks post-operatively. Results In comparison with the Sham group, the IT group showed a higher GLP-1 level and lower AUC at 4, 8, 16 and 24 weeks post-operatively (all P < 0.05) and a lower FPG, F-ins levels and HOMA-IR at 8, 16 and 24 weeks post-operatively (all P < 0.05). Compared with baseline levels, the plasma GLP-1, AUC and FPG levels decreased significantly at each post-operative time point in the IT group (all P < 0.05), but not in the Sham group (all P > 0.05); F-ins and HOMA-IR significantly decreased at 8, 16 and 24 weeks post-operatively in the IT group (all P < 0.05). GLP-1R expression in the IT group was significantly higher than that of the Sham group in both the pancreas and the ileum at 24 weeks post-operatively (P < 0.05). Conclusions Ileal transposition ameliorated glucose metabolism without reduction in weight or food intake in GK rats, which may be induced by the increased GLP-1 expression. However, the delayed improvement of insulin resistance, accompanied by decreased plasma insulin levels, might not directly result from the increased GLP-1. |
| Starting Page | 291 |
| Ending Page | 297 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 30430018v1 |
| Alternate Webpage(s) | https://doi.org/10.1093/gastro/goy027 |
| DOI | 10.1093/gastro/goy027 |
| Journal | Gastroenterology report |
| Volume Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Area Under Curve BaseLine dental cement Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Eating Glucagon Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Insulin Resistance Obesity Oral Glucose Tolerance Test Pancreas extract glucose metabolism |
| Content Type | Text |
| Resource Type | Article |
