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Synthesis of 2,3-disubstituted indole using palladium(II)-catalyzed cyclization with alkenylation reaction.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yasuhara, Akito Takeda, Yousuke Suzuki, Naoyuki Sakamoto, Takao |
| Copyright Year | 2002 |
| Abstract | The reaction of ethyl 2-ethynylphenylcarbamate derivative with alkenes in the presence of a palladium(II) catalyst, copper dichloride and tetrabutylammonium fluoride (TBAF) produced 2-substituted 3-ethenylindoles during refluxing. The intramolecular cyclization reaction of ethyl 2-ethynylphenylcarbamates, which have an ethenyl part in the ethynyl group, was also used to produce carbazole derivatives. |
| Starting Page | 1 |
| Ending Page | 7 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cpb.pharm.or.jp/cpb/200202/c02_0235.pdf |
| PubMed reference number | 11848216v1 |
| Volume Number | 50 |
| Issue Number | 2 |
| Journal | Chemical & pharmaceutical bulletin |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alkenes Amine Oxidase (Copper-Containing) Cyclization Reflux Secologanin Tryptamine Alkaloids carbazole icosapent ethyl tetrabutylammonium fluoride |
| Content Type | Text |
| Resource Type | Article |