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Interrelationships between Ki 67 , p 53 with ER , PR & HER 2 / neu , Status and their Associations with Tumor Grade in Infiltrating Duct Carcinoma Breast
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ghanghoria, Shikha Sharma, Sachin Jahan, Ishrat Jain, Amit |
| Copyright Year | 2019 |
| Abstract | Introduction: Breast cancer is the most common malignancy occurring in females, accounting for 23% of all malignant tumors. Over 1 lakh new breast cancer patients are estimated to be diagnosed every year in India. It is expected to increase by 26% by 2020 in developing countries. Various predictive and prognostic factors affect tumor progression including tumor grade, ER, PR, Her2neu, Ki-67 & p53 over expression. Aims: 1) To correlate p53 and Ki 67 expression with ER PR & her2/neu expression in carcinoma breast. 2) To study p53 and Ki-67 expression in different grades of carcinoma breast. Methods and Material: A Retrospective and prospective study of 100 cases of carcinoma breast in M.Y. Hospital Indore during 3 year duration. Patient’s information was extracted from hospital records regarding age, tumor size, histological grade of tumor, ER and PR, HER2/neu status. Immunohistochemistory was performed on histopathology sections to know p53 and Ki67 expression. Result: Percentage expression of different tumor markers are ER 32 %, PR 31%, HER2/neu 12%, and triple negative 65%, p53 61.2% and ki-67 is 55%. Ki-67 maximum express with luminal-A tumors. 52.3% ER PE positive tumor show p53 expression. Ki-67 and p53 expression maximum with grade III. Conclusion: Breast cancer patients with higher Ki67 expression showed more HER2/neu overexpression, and these cancers may be identified as aggressive tumors. Moreover, in young patients with breast carcinoma, the rates of Ki67 with overexpression of HER2/neu and p53. mutation were higher, and it is shown to be indicative of a more invasive tumor and a higher frequency of metastasis. However, p53 mutation was seen with higher tumor grades. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ijsr.net/archive/v8i2/ART20195224.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
