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Prognostic classification of Breast carcinoma on molecular basis using ER , PR , Her-2 / neu and ki 67 : A study conducted on 45 patients in RIMS , Ranchi , Jharkhand , India
| Content Provider | Semantic Scholar |
|---|---|
| Author | Singh, Rabindra Kumar Banerjee, Saurav Shrivastav, R. K. Bharati, Purnima Sinha, Anil Kumar |
| Copyright Year | 2016 |
| Abstract | Objective: To classify the cases of breast carcinoma coming to RIMS, Ranchi into Luminal A,B,Her-2/neu and basal like using IHC Markers-ER,PR,Her-2/neu and ki67 Materials and methods: In our study on 45 patients with breast carcinoma, all of them being women were taken into account and the expression of Hormonal ,markers ER,PR, Her-2 and ki67 were determined by immunohistochemistry and classification into Luminal A,B,Her-2 and Basal like were done subsequently. Results: The mean age of patients was 53.17 years. Of 45 patients, 17 patients (37.77%) had breast cancer with metastasis and 28(62.22%) without metastasis. Nottingham modification of Scarff Bloom Richardson grading was-Grade I in 18 patients, Grade II in 15 patients and Grade III in 12 patients. Depending on IHC markers ER, PR, Her-2/neu and ki67,Luminal A patients were 34(75.55%),Luminal B were 8(17.77%),Her-2/neu1(2.22%) and Basal like-2(4.44%). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.iosrjournals.org/iosr-jdms/papers/Vol15-Issue%2012/Version-5/C1512051214.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
