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Nitric oxide inhibitors attenuate ischemic degeneration in the CA1 region of rat hippocampal slices
| Content Provider | Semantic Scholar |
|---|---|
| Author | Izumi, Yukitoshi Benz, Ann M. Clifford, David B. Zorumski, Charles F. |
| Copyright Year | 1996 |
| Abstract | We examined the involvement of nitric oxide (NO) in ischemic brain damage using hippocampal slices prepared from 30 day old albino rats and exposed to 20 min of oxygen/glucose deprivation (ischemia) followed by 90 min postincubation in oxygen- and glucose-containing media. Damage in the CA1 region was rated on a 0 (intact) to 4 (severe neuronal damage) scale by a rater blind to the experimental condition. Control slices exposed to ischemia were rated as 2.8 +/- 0.4 (N = 12). L-NG-Monomethylarginine (100 microM) and L-NG-nitroarginine (100 microM), non-selective NO synthase (NOS) inhibitors, diminished ischemic damage (0.6 +/- 0.3, N = 8, and 1.0 +/- 0.5, N = 4, respectively). An inhibitor of brain NOS, 7-nitroindazole (30 microM), was also effective against ischemic degeneration (0.7 +/- 0.3, N = 5). These results suggest that activation of NOS is involved in ischemic degeneration in the CA1 region. |
| Starting Page | 157 |
| Ending Page | 160 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(96)12669-0 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394096126690 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394096126690?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 8805119 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2896%2912669-0 |
| Journal | Medline |
| Volume Number | 210 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
