Differential responses between CA1 pyramidal cells and granule cells to ischemic insult in rat hippocampal slices

Content Provider	Semantic Scholar
Author	Shimizu, Hitoshi Mizuguchi, Akira Aoki, Mamoru
Copyright Year	1996
Abstract	Differential responses between CA1 pyramidal cells (PCs) and granule cells (GCs) to transient ischemic insults (oxygen and glucose deprivation, Hypo center dot G(-)) were studied in rat hippocampal slices using simultaneous recordings of membrane potentials and intracellular Ca2+ concentrations ([Ca2+]i). The average resting membrane potentials before Hypo center dot G(-) were significantly different between PCs (-66.5 +/- 1.5 mV) and GCs (-78.5 +/- 2.0 mV). In PCs, Hypo center dot G(-) produced an initial hyperpolarization and a subsequent rapid and large depolarization. In contrast, in GCs, Hypo center dot G(-) produced a gradual depolarization with an initial slight hyperpolarization. [Ca2+]i increased corresponding to the depolarization. The [Ca2+]i levels during Hypo center dot G(-) and after reoxygenation were significantly higher in the CA1 than in the dentate gyrus. These results suggest that PCs are more susceptible to Hypo center dot G(-) than GCs, as judged by the speed of depolarization and the elevation in [Ca2+]i.
Starting Page	195
Ending Page	198
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(95)12293-1
PubMed reference number	8742026
Journal	Medline
Volume Number	203
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394095122931
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394095122931?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2895%2912293-1
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article