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DNA microarray fabrication and processing : Automation in the laboratory
| Content Provider | Semantic Scholar |
|---|---|
| Author | Verdun, Katrine Rouse, Richard Biogem, Gary Hardiman |
| Copyright Year | 2002 |
| Abstract | The confluence of robotics, biotechnology, computer sciences and the completion of genome sequencing efforts for several organisms, have resulted in revolutionary changes in how biomedical research is carried out. It is now possible to fabricate high-density arrays of specified DNA sequences that include every known gene of an organism on a single glass slide. Labeled RNA or DNA targets (such as messenger RNAs obtained from cells, tissues or organisms under different conditions) can be analyzed by hybridization on the array. Differences in the levels of expression for thousands of genes can thus be assessed all at the same time in a single, simple experiment. Genomics, informatics and automation are playing increasingly important roles as discovery tools in the basic biological sciences, and as diagnostic and rational therapeutic aids in the clinical arena. We discuss the use of automation to increase productivity in microarray fabrication and describe how automated procedures increase the quality of results in microarray experimentation. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://microarrays.ucsd.edu/biogem/pdf/ISLAR2001.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
