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Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Werner, Ernst R. Werner-Felmayer, G. Fuchs, Dietmar Hausen, A. Reibnegger, Gilbert Wachter, Helmut |
| Copyright Year | 1989 |
| Abstract | In all of eight tested human cells and cell lines with inducible indoleamine 2,3-dioxygenase (EC 1.13.11.17) tetrahydrobiopterin biosynthesis was activated by interferon-gamma. This was demonstrated by GTP cyclohydrolase I (EC 3.5.4.16) activities and intracellular neopterin and biopterin concentrations. Pteridine synthesis was influenced by extracellular tryptophan. In T 24-cell extracts, submillimolar concentrations of tetrahydrobiopterin stimulated the indoleamine 2,3-dioxygenase reaction. |
| File Format | PDF HTM / HTML |
| DOI | 10.1042/bj2620861 |
| PubMed reference number | 2511835 |
| Journal | Medline |
| Volume Number | 262 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/262/3/861.full.pdf |
| Journal | The Biochemical journal |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |