NDLI: Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.

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Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.

Content Provider	Semantic Scholar
Author	Chung, Ting Wen Tan, Kok-Tong Chan, Hong-Lin Lai, Ming-Derg Yen, Meng-Chi Lin, Sheng Hao Lin, Chi-Chen
Copyright Year	2014
Abstract	Interferon-gamma (IFN-γ) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-γ are poorly understood. In the present study, we examined the in vitro antitumor activity of IFN-γ on two human non-small-cell lung carcinoma (NSCLC) cell lines, H322M and H226. Our findings indicated that IFN-γ treatment caused a time-dependent reduction in cell viability and induced apoptosis through a FADD-mediated caspase-8/tBid/mitochondria-dependent pathway in both cell lines. Notably, we also postulated that IFN-γ increased indoleamine 2,3-dioxygenase (IDO) expression and enzymatic activity in H322M and H226 cells. In addition, inhibition of IDO activity by the IDO inhibitor 1-MT or tryptophan significantly reduced IFN-γ-induced apoptosis and death receptor 5 (DR5) expression, which suggests that IDO enzymatic activity plays an important role in the anti-NSCLC cancer effect of IFN-γ. These results provide new mechanistic insights into interferon-γ antitumor activity and further support IFN-γ as a potential therapeutic adjuvant for the treatment of NCSLC.
Starting Page	7995
Ending Page	8001
Page Count	7
File Format	PDF HTM / HTML
DOI	10.7314/APJCP.2014.15.18.7995
PubMed reference number	25292102
Journal	Medline
Volume Number	15
Issue Number	18
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/apocp/POCPA9/2014/v15n18/POCPA9_2014_v15n18_7995.pdf
Alternate Webpage(s)	https://doi.org/10.7314/APJCP.2014.15.18.7995
Journal	Asian Pacific journal of cancer prevention : APJCP
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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